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Circulating testosterone did not change in the treatment group, but significantly decreased ( p = 0.015) in controls with a significant difference over time within subjects ( p = 0.018) and between subjects ( p = 0.012)

The DECLARE, CANVAS and EMPA-REG CV outcomes trials assessing the SGLT2 inhibitors dapagliflozin (Farxiga, AstraZeneca), canagliflozin (Invokana, Janssen) and empagliflozin (Jardiance, Boehringer Ingelheim/Eli Lilly), respectively, all showed CV and renal benefit in adults with type 2 diabetes with established CVD, DeFronzo said

Discuss with your healthcare team if you need dose adjustments of these medications

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